The two classes that lower triglycerides and raise HDL (high-density lipoprotein), and how to tell every class apart on the lipid profile. Fibrates activate PPAR-alpha and cause gallstones; niacin flushes (take aspirin first) and raises uric acid and glucose. Watch the flip: the class that treats very high triglycerides is not the one that is contraindicated by them. What these do and do not ask. Indications, adverse effects, contraindications and patient education are in, weighted above mechanism. Doses are out, and so are risk calculations and choosing a statin intensity for a given patient, which is why the sets run 14 to 16 rather than the usual 30. Every option carries its own reason, correct and incorrect alike.
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