Every antihistamine on the slides side by side: how long it lasts, and how sedating, antiemetic and anticholinergic it is. First-generation agents are the sedating ones.
| Drug | Generation | Duration (hours) | Sedative effects | Antiemetic effects | Anticholinergic effects | Source |
|---|---|---|---|---|---|---|
| Chlorpheniramine Chlor-Trimeton | First generation | 6 | Medium | None | Medium | L5 slide 37 |
| Dimenhydrinate Dramamine | First generation | 8 | High | Medium | High | L5 slide 37 |
| Diphenhydramine Benadryl | First generation | 8 | High | Medium | High | L5 slide 37 |
| Hydroxyzine Atarax | First generation | 6 | High | High | Medium | L5 slide 37 |
| Meclizine Antivert | First generation | 12 | Medium | High | Medium | L5 slide 37 |
| Promethazine Phenergan | First generation | 12 | High | High | High | L5 slide 37 |
| Cetirizine Zyrtec | Second generation | 24 | Low | None | Very low | L5 slide 37 |
| Fexofenadine Allegra | Second generation | 12 | Very low | None | Very low | L5 slide 37 |
| Loratadine Claritin | Second generation | 24 | Very low | None | Very low | L5 slide 37 |
| Azelastine Astelin | Intranasal | 12 | Low | None | Very low | L5 slide 37 |