Pharmacology I · Exam 2 · Class of 2028

Non-Selective Beta Blockers Compared

The first-generation beta blockers on the slides, by membrane-stabilizing activity, lipid solubility and intrinsic sympathomimetic activity.

Lecture 6 — Antihypertensive Drugs 6 rows

Lipid solubility predicts central nervous system effects (depression, nightmares, vivid dreams): propranolol and penbutolol are the highly lipid-soluble ones. Pindolol has the most intrinsic sympathomimetic activity, meaning it partly stimulates the receptor it blocks. (The lecturer said not to memorize the plus counts; know the pattern.)

Drug	Group	Membrane stabilizing	Lipid solubility	Intrinsic sympathomimetic activity (ISA)	Source
Nadolol Corgard	Non-selective (first generation)	0	Low	0	L6 slide 60
Penbutolol Levatol	Non-selective (first generation)	0	High	+	L6 slide 60
Pindolol Visken	Non-selective (first generation)	+	Low	+++	L6 slide 60
Propranolol Inderal	Non-selective (first generation)	++	High	0	L6 slide 60
Sotalol Betapace	Non-selective (first generation)	0	Low	0	L6 slide 60
Timolol Blocadren	Non-selective (first generation)	0	Moderate	0	L6 slide 60

Every row is checked against the slide it cites by tools/check_pharm_e2.py before this page is written.

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